Takanari Inoue, Professor of GIR, won “JSPS Prize” from Japan Society for the Promotion of Science on December 17, 2020.
“Japan Society for the Promotion of Science (JSPS) Prize”
◆Outline of the award
“Elucidation of Primary Cilia Functions with Innovative Molecular Tools”
Primary cilia exist in most cell species and play an important physiological function as a cell antenna. However, because there is only one primary cilium per cell and its diameter is only 200-300 nanometers, the study was challenging. Taking advantage of being well versed in organic chemistry and cell biology, Professor Takanari Inoue independently developed a new cell manipulation technology that instantly visualizes and manipulates signal molecules within the primary cilia, and discovered for the first time in the world that the lipid molecules in primary cilia determines the fate of primary cilia, and elucidated the substances and information transmission mechanisms in and around the primary cilia on the molecular level. He also presented a whole new concept that the torn tip of the primary cilia functions remotely as a signal molecule, which has had a great impact on the field of cell biology. Furthermore, he made reversible control and optical control possible by applying the basic technology he had developed and was highly regarded internationally on clarifying the control mechanism of ion channels and the molecular mechanism of physiological phenomena such as cell migration.
As stated above, Prof. Inoue has achieved many original research results up to this time, and is expected to play an even more active role as a leading researcher in the world of life science.