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USUI Tatsuya

Position

Associate Professor

Affiliations

Division of Animal Life Science, Institute of Agriculture
Life Science - Usui Team, Institute of Global Innovation Research

Researcher ID

Q-5170-2017

0000-0002-1818-2127

Professional Career

2011/04/01 - 2013/03/31 : Research fellow, JSPS (DCI1, Agriculture)
2013/04/01 - 2013/10/31 : Research fellows, JSPS (PD, Agriculture)
2013/11/01 - 2017/08/31 : Associate Professor, Joint Faculty of Veterinary Medicine, Yamaguchi University,
2015/04/01 - 2015/09/30 : Visiting professor, School of Medicine, Stanford University
2017/09/01 - 2022/08/31 : Senior Assistant Professor, Division of Animal Life Science, Tokyo University of Agriculture and Technology
2022/09/01 - Present : Associate Professor, Division of Animal Life Science, Tokyo University of Agriculture and Technology

Academic Degrees

2013/03 PhD. in veterinary medicine, Kitasato University

Research Interests

Veterinary pharmacology, cancer, 3D culture, metabolic syndrome disease

Publications

  • Ting-Wei Y, Yamamoto H, Morita S, Fukushima R, Elbadawy M, Usui T, Sasaki K. Comparative pharmacokinetics of tyrosine kinase inhibitor, lapatinib, in dogs and cats following single oral administration. Jornal of Veterinary Medical Science, 86(3):317-321, 2024.
  • Elbadawy M, Tanabe K, Yamamoto H, Ishihara Y, Mochizuki M, Abugomaa A, Yamawaki, H, Kaneda, M, Usui, T, Sasaki, K. Evaluation of the efficacy of mitochondrial fission inhibitor (Mdivi-1) using non-alcoholic steatohepatitis (NASH) liver organoids. Frontiers in Pharmacology, 14. 1243258. 2023
  • Nabeta R, Kanaya A, Elbadawy M, Usui T, Furuya T, Suzuki K, Uchide T. Chemosensitivity of Three Patient-derived Primary Cultures of Canine Pericardial Mesothelioma by Single agent and Combination Treatment. Frontiers in Veterinary Science, 10, 1267359. 2023.
  • Hussein M, Eman A, Usui T, Ishihara Y, Yoshida T, Kobayashi M, Sasaki K, Ma D, Yairo A, Mandour A, Hendawy H, Doghish A, Mohammed O, Takahashi K, Tanaka R. Adipose Stem Cell-Seeded Decellularized Porcine Pericardium: A Promising Functional Biomaterial to Synergistically Restore the Cardiac Functions Post-Myocardial Infarction. Veterinary Science. 10, 10.3390. 2023.
  • Ameen A. Salahudeen,, Jose A. Seoane, Kanako Yuki, Amanda T. Mah, Amber R. Smith, Kevin Kolahi, Sean M. De la O, Daniel J. Hart, Jie Ding, Zhicheng Ma, Sammy A. Barkal, Navika D. Shukla,Chuck H. Zhang, Michael A. Cantrell, Arpit Batish, Usui T, David Root, William Hahn, Christina Curtis,and Calvin J. Kuo. Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis. Cell Reports,42(11):113355, 2023.
  • Hussein M, Eman A, Kaneda M, Shimada K, Nakazawa Y, Usui T, Elbadawy M, Ishihara Y, Hirose M, Kamei Y, Ahmed S, Hesham A, El-Malaa A, Walla A, Taknaka R. Comparison of Bovine- and Porcine-Derived Decellularized Biomaterials: Promising Platforms for Tissue Engineering Applications. Pharmaceutics. 15, 1906. 2023.
  • Sato Y, Elbadawy M, Suzuki K, Tsunedomi R, Nagano H, Ishihara Y, Yamamoto H, Azakami D, Uchide T, Fukushima R, Tanaka R, Yoshida T, Mori T, Abugomaa A, Kaneda M, Yamawaki H, Shinohara Y, Aboubakr M, El-Asrag, M, Usui, T, Sasaki, K. Derivation of a new model of lung adenocarcinoma using canine lung cancer organoids for translational research in pulmonary medicine. Biomedicine & Pharmacotherapy, 165: 115079. 2023
  • Abugomaa A, Elbadawy M, Ishihara Y, Yamamoto H, Kaneda, M, Yamawaki, H, Shinohara Y, Usui, T, Sasaki, K. Anti-cancer activity of Chaga mushroom (Inonotus obliquus) against dog bladder cancer organoids, Frontiers in Pharmacology, 14:1159516.2023
  • Sato Y, Elbadawy M, Suzuki K, Tsunedomi R, Nagano H, Ishihara Y, Yamamoto H, Azakami D, Kaneda M, Ishihara, Y, Sato, Y, Yamawaki, H, Kaneda, M, Usui, T, Sasaki, K. Establishment of an experimental model of canine malignant mesothelioma organoid culture using a three-dimensional culture method. Biomedicine & Pharmacotherapy162: 114651. 2023
  • Abugomaa A, Elbadawy M, Yamamoto H, Ayame, H, Ishihara, Y, Sato, Y, Yamawaki, H, Kaneda, M, Usui, T, Sasaki, K. Establishment of a direct 2.5D organoid culture model using companion animal cancer tissues. Biomedicine & Pharmacotherapy. 154:113597. 2022.
  • Shinohara Y, Elbadawy M, Yamanaka M, Yamamoto H, Abugomaa A, Usui T, Sasaki K. Effect of the liquid form of traditional Chinese medicine, Hozen-S, on gastric motility in dogs. Journal of Veterinary Medical Science. 84:841-846.2022.
  • Yoshida, T., Kobayashi, M., Uomoto, S., Ohshima, K., Hara, E., Katoh, Y., Takahashi, N., Harada, T., Usui, T., Elbadawy, M., Shibutani, M.: The potential of organoids in toxicologic pathology: role of toxicologic pathologists in in vitro chemical hepatotoxicity assessment. Journal of Toxicologic Pathology (J. Toxicol. Pathol.) 35(3): 225–235, 2022.
  • Elbadawy M, Fujisaka K, Yamamoto H, Tsunedomi R, Nagano H, Ayame H, Ishihara Y, Mori T, Azakami D, Uchide T, Fukushima R, Abugomaa A, Kaneda M, Hideyuki M Yamawaki, Shinohara Y, Omatsu T, Mizutani T, Usui T, Sasaki K. Establishment of an experimental model of normal dog bladder organoid using a three-dimensional culture method. Biomedicine & Pharmacotherapy. 151:113105. 2022.
  • Elbadawy M, Kato Y, Saito N, Hayashi K, Abugomaa A, Kobayashi M, Yoshida T, Shibutani M, Kaneda M, Yamawaki H, Mizutani T, Lim CK, Saijo M, Sasaki K, Usui T, Omatsu T. Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-Associated Viruses, SARS-CoV-2 and Pteropine Orthoreovirus. Int J Mol Sci. 2021 Oct 5;22(19):10763
  • Endo T, Nakagomi Y, Kawaguchi E, Hayakawa ESH, Vu HN, Takemae H, Shinohara Y, Yang D, Usui T, Mizutani T, Nakao Y, Furuya T. Anti-malarial activity in a Chinese herbal supplement containing Inonotus obliquus and Panax notoginseng. Parasitol Int. 2022 Dec 18;87:102532. doi: 10.1016/j.parint.2021.102532. Epub ahead of print. PMID: 34933121.
  • Elbadawy M, Kato Y, Saito N, Hayashi K, Abugomaa A, Kobayashi M, Yoshida T, Shibutani M, Kaneda M, Yamawaki H, Mizutani T, Lim C-K, Saijo M, Sasaki K, Usui T, Omatsu T. Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-associated Viruses, SARS-CoV-2 and Pteropine orthoreovirus. International Journal of Molecular Sciences, 22 (19) 10763, 2021
  • Yamamoto H, Elbadawy M, Fujisaka K, Sato Y, Ohmori T, Shinohara Y, Hatano Y, Kobayashi D, Gomyo A, Sudo Y, Azakami D, Uchide T, Fukushima R, Morita S, Abugomaa A, Yamawaki H, Kaneda M, Usui T, Sasaki K. Evaluation of the Safety and Feasibility of Apheresis in Dogs: For Application in Metastatic Cancer Research. Animals 11 (10) :2770, 2021
  • Elbadawy, M., Hayashi, K., Ayame, H., Ishihara, Y., Abugomaa, A., Shibutani, M., Hayashi, S. M., Hazama, S., Takenouchi, H., Nakajima, M., Tsunedomi, R., Suzuki, N., Nagano, H., Shinohara, Y., Kaneda, M., Yamawaki, H., Usui, T., Sasaki, K.: Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids. Biomed. Pharmacother. 142, 112043, 2021. https://doi.org/10.1016/j.biopha.2021.112043
  • Elbadawy, M., Sato, Y., Mori, T., Goto, Y., Hayashi, K., Yamanaka, M., Azakami, D., Uchide, T., Fukushima, R., Yoshida, T., Shibutani, M., Kobayashi, M., Shinohara, Y., Abugomaa, A., Kaneda, M., Yamawaki, H., Usui, T., Sasaki, K.: Anti-tumor effect of trametinib in bladder cancer organoid and the underlying mechanism. Cancer Biol. Ther. 22(5-6), 357–371, 2021. https://doi.org/10.1080/15384047.2021.1919004
  • Abugomaa, A., Elbadawy, M., Yamanaka, M., Goto, Y., Hayashi, K., Mori, T., Uchide, T., Azakami, D., Fukushima, R., Yoshida, T., Shibutani, M., Yamashita, R., Kobayashi, M., Yamawaki, H., Shinohara, Y., Kaneda, M., Usui, T., Sasaki, K., Establishment of 2.5D organoid culture model using 3D bladder cancer organoid culture. Scientific Reports, 10(1), 9393, 2020.
  • Elbadawy, M., Yamanaka, M., Goto, Y., Hayashi, K., Tsunedomi, R., Hazama, S., Nagano, H., Yoshida, T., Shibutani, M., Ichikawa, R., Nakahara, J., Omatsu, T., Mizutani, T., Katayama, Y., Shinohara, Y., Abugomaa, A., Kaneda, M., Yamawaki, H., Usui, T., Sasaki, K.: Efficacy of primary liver organoid culture from different stages of non-alcoholic steatohepatitis (NASH) mouse model. Biomaterials 237:119823, 2020
  • Elbadawy, M., Usui, T., Mori, T., Tsunedomi, R., Hazama, S., Nabeta, R., Uchide, T., Fukushima, R., Yoshida, T., Shibutani, M., Tanaka, T., Masuda, S., Okada, R., Ichikawa, R., Omatsu, T., Mizutani, T., Katayama, Y., Noguchi, S., Iwai, S., Nakagawa, T., Shinohara, Y., Kaneda, M., Yamawaki, H., Sasaki, K. Establishment of a novel experimental model for muscle-invasive bladder cancer using a dog bladder cancer organoid culture. Cancer Science (Cancer Sci.). 110(9):2806-2821, 2019.
  • Nabeta R, Nakagawa Y, Chiba S, Xiantao H, Usui T, Suzuki K, Furuya T, Fukushima R, Uchide T. Pericardial Mesothelioma in a Dog: The Feasibility of Ultrasonography in Monitoring Tumor Progression. Front Vet Sci. 2019 Apr 18;6:121. doi: 10.3389/fvets.2019.00121. eCollection 2019.

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