YOSHIDA Toshinori

Professional Career

1990.04-2013.09 : Institute of Environemntal Toxicology
2004.09-2007.03 : Research Fellow, Division of Cardiopulmonary Pathology, Department of Pathology, Johns Hopkins University School of Medicine, USA
1997.09-1998.03 : Researcher, Department of Biochemistry and Molecular Oncology, University of Tsukuba, School of Medicine, Tsukuba, Japan
1995.09-1996.03 : Visiting Researcher, Department of Toxicology and Microbiology, Institute of Life Sciences and Faculty of Pharmaceutical Sciences, Tokyo University of Science
1992.01-1992.05 : Visiting Research Fellow, First Department of Pathology, Nagoya City University School of Medicine
2014.04-2023.09 : Associate Professor, Tokyo University of Agriculture and Technology
2023.10-presemt : Professor, Tokyo University of Agriculture and Technology

Academic Degrees

Ph.D.(The University of Tokyo)

Research Interests

Chemical toxicity, Chemical carcinogenesis, Developmental neurotoxicity, Experimental pathology

Publications

• Kasamatsu K, Lola MSG, Yoshida T, Kigata T. Lobation and vascularity of the liver in the red-eared slider (Trachemys scripta elegans). Anat Rec (Hoboken). 2026 Jan 16. doi: 10.1002/ar.70132. Epub ahead of print. PMID: 41540932.
• Ojiro R, Zou X, Yamagata H, Ebizuka Y, Kobayashi M, Kigata T, Tang Q, Yoshida T, Yoshinari T, Shibutani M. Emerging mycotoxin moniliformin induces renal tubular necrosis after oral exposure in mice. Food Chem Toxicol. 2025 May;199:115336. doi: 10.1016/j.fct.2025.115336.
• Luo M, Himeno K, Sakai K, Lola MSG, Shibutani M, Yoshida T, Kigata T. Traumatic dorsolateral diaphragmatic hernia in a juvenile raccoon dog (Nyctereutes viverrinus viverrinus). J Vet Med Sci. 2026 Jan 1;88(1):62-65. doi: 10.1292/jvms.25-0261.
• Yamamoto H, Elbadawy M, Tsunedomi R, Maeda N, Nagano H, Ishihara Y, Abugomaa A, Shiota Y, Yu TW, Liu Y, Nagashima Y, Kobayashi Y, Matsui R, Uomoto S, Kobayashi M, Yoshida T, Shibutani M, Kobayashi T, Inoue M, Higashinaka M, Fukushima R, Azakami D, Uchide T, Shinohara Y, Yamawaki H, Kaneda M, Usui T, Sasaki K. Novel organoid-based exploration reveals the role of LMTK3/FADS2 signaling in metastatic breast cancer progression in felines and humans. Sci Rep. 2025 Nov 22;15(1):45016. doi: 10.1038/s41598-025-28751-7.
• Watanabe N, Kobayashi M, Kuriki T, Ebizuka Y, Hirata M, Mizuguchi R, Takimoto M, Yidan B, Luo M, Todoroki M, Lola MSG, Zou X, Jiang S, Kigata T, Shibutani M, Yoshida T, Omatsu T. Wnt and Treg-Associated Signaling Coordinate Mucosal Regeneration and MALT Formation in a Mouse Model of Chronic Colitis. Int J Mol Sci. 2026 Jan 13;27(2):779. doi: 10.3390/ijms27020779.
• Tang Q, Ojiro R, Ozawa S, Zou X, Nakahara J, Nakao T, Koyanagi M, Jin M, Yoshida T, Shibutani M. DNA methylation-altered genes in the rat hippocampal neurogenic niche after continuous exposure to amorphous curcumin. J Chem Neuroanat. 2024 Apr;137:102414. doi: 10.1016/j.jchemneu.2024.102414.
• Ozawa S, Ojiro R, Tang Q, Zou X, Jin M, Yoshida T, Shibutani M. Involvement of multiple epigenetic mechanisms by altered DNA methylation from the early stage of renal carcinogenesis before proliferative lesion formation upon repeated administration of ochratoxin A. Toxicology. 2024 Aug;506:153875. doi: 10.1016/j.tox.2024.153875.
• Zou X, Tang Q, Ojiro R, Ozawa S, Shobudani M, Sakamaki Y, Ebizuka Y, Jin M, Yoshida T, Shibutani M. Increased spontaneous activity and progressive suppression of adult neurogenesis in the hippocampus of rat offspring after maternal exposure to imidacloprid. Chem Biol Interact. 2024 Aug 25;399:111145. doi: 10.1016/j.cbi.2024.111145.
• Shobudani M, Sakamaki Y, Karasawa A, Ojiro R, Zou X, Tang Q, Ozawa S, Jin M, Yoshida T., Shibutani M. Metabolic shift as a compensatory response to impaired hippocampal neurogenesis after developmental exposure to sodium fluoride in rats. Acta Histochem. 2024 Dec;126(8):152204. doi: 10.1016/j.acthis.2024.152204.
• Kobayashi M, Usui T, Elbadawy M, Kigata T, Kaneda M, Murakami T, Kozono T, Itoh Y, Shibutani M, Yoshida T. Anorectal Remodeling in the Transitional Zone with Increased Expression of LGR5, SOX9, SOX2, and Keratin 13 and 5 in a Dextran Sodium Sulfate-Induced Mouse Model of Ulcerative Colitis. Int J Mol Sci. 2024 Nov 26;25(23):12706. doi: 10.3390/ijms252312706.
• Elbadawy M, Saito N, Kato Y, Hayashi K, Abugomaa A, Kobayashi M, Yoshida T, Shibutani M, Kaneda M, Yamawaki H, Sasaki K, Usui T, Omatsu T. Establishment of a bat lung organoid culture model for studying bat-derived infectious diseases. Sci Rep. 2025 Feb 3;15(1):4035. doi: 10.1038/s41598-025-88621-0.