ASANO Ryutaro

Professional Career

Apr. 2000 - Nov. 2002 : Research Associate, Cell Resource Center for Biomedical Research, Institute of Development, Aging, and Cancer, Tohoku University
Dec. 2002 - Mar. 2007 : Research Associate, Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University
Feb. 2003 - Mar. 2005 : Research Associate (concurrent post), Cell Resource Center for Biomedical Research, Institute of Development, Aging, and Cancer, Tohoku University
Apr. 2007 - Dec. 2010 : Assistant Professor, Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University
Jan. 2011 - Aug. 2015 : Associate Professor, Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University
Sep. 2015 - Aug. 2020 : Associate professor, Tokyo University of Agriculture and Technology
Sep. 2020 - Present : Associate Professor(Tenured), Tokyo University of Agriculture and Technology

Academic Degrees

Dec. 2006 : Ph.D. in Engineering, Tohoku University

Research Interests

Immunosensing, Protein engineering, Antibody engineering

Publications

• Hiraka, K., Yoshida, H., Tsugawa, W., Asano, R., LaBelle, J., Ikebukuro, K., Sode, K. Structure of lactate oxidase from Enterococcus hirae revealed new aspects of active site loop function: Product-inhibition mechanism and oxygen gatekeeper. Protein Science (Protein Sci.). 31:e4434, 2022
• Saito, T., Shimizu, Y., Tsukakoshi, K., Abe, K., Lee, J.H., Ueno, K., Asano, R., Jones, B.V., Yamada, T., Nakano, T., Tong, J., Asami, H., Harada, K., Hashimoto, H., Sode, K., Toyo’oka, T..Todoroki, K., Ikebukuro, K. Development of a DNA aptamer that binds to the complementarity-determining region of therapeutic monoclonal antibody and affinity improvement induced by pH-change for sensitive detection, Biosens. Bioelectron., 203, 114027. doi: 10.1016/j.bios.2022.114027., 2022
• Khanwalker M, Fujita R, Lee J, Wilson E, Ito K, Asano R, Ikebukuro K, LaBelle J, Sode K, Development of a POCT type insulin sensor employing anti-insulin single chain variable fragment based on faradaic electrochemical impedance spectroscopy under single frequency measurement, Biosens, Bioelectron., 200, 113901, doi: 10.1016/j.bios.2021.113901, 2022
• Tsukakoshi, K., Yoshida, W., Kobayashi, M., Kobayashi, N., Kim, J., Kaku, T., Iguchi, T., Nagasawa, K., Asano, R., Ikebukuro, K., Sode, K. Esterification of PQQ Enhances Blood-Brain Barrier Permeability and Inhibitory Activity against Amyloidogenic Protein Fibril Formation. ACS Chemical Neuroscience (ACS Chem Neurosci). doi: 10.1021/acschemneuro.8b00355, 9:12: 2898-2903
• Miyazaki, R., Yamazaki,T., Yoshimatsu, K., Kojima, K., Asano, R., Sode, K., Tsugawa, W. Elucidation of the intra- and inter-molecular electron transfer pathways of glucoside 3-dehydrogenase. Bioelectrochemistry. 122:115-122, 2018
• Asano, R., Kuroki, Y., Honma, S., Akabane, M., Watanabe, S., Mayuzumi, S., Hiyamuta, S., Kumagai, I., Sode, K. Comprehensive study of domain rearrangements of single-chain bispecific antibodies to determine the best combination of configurations and microbial host cells. MAbs. 10(6):854-863, 2018
• Hiraka, K., Kojima, K., Lin, C.E., Tsugawa, W., Asano, R., La Belle, J.T., Sode, K. Minimizing the effects of oxygen interference on l-lactate sensors by a single amino acid mutation in Aerococcus viridansl-lactate oxidase. Biosensors and Bioelectronics (Biosens. Bioelectron). 103:163-170, 2018