INADA Masaki

Professional Career

2005 : Visiting Fellow, Medical School, Harvard University
2008 - present : Associate Professor, Tokyo University of Agriculture and Technology
2012 : Visiting Associate Professor, Waseda University
2016 : Visiting Professor, The Nippon Dental University
2017 : Visiting Researcher, National Center of Neurology and Psychiatry

Academic Degrees

1997 Ph.D. in Dentistry, The Nippon Dental University

Research Interests

Disuse Atrophy, Osteoporosis, Bone metastases, Matrix metalloproteinase

Publications

• Egorova, D., Kerever, A., Inada, M., Itoh, Y., Arikawa-Hirasawa, E., Miyata, S. Microglial depletion increases aggrecan and hyaluronan levels in the diffuse and aggregated extracellular matrix of the mouse brain. Scientific Reports, 15:9376. doi: 10.1038/s41598-025-94224-6
• Hirata, M., Tominari, T., Matsumoto, C., Kasuga, U., Ikeda, K., Miyaura, C., Grundler, F.M.W., Inada, M. Polymethoxyflavones and bone metabolism. Nutrients.
• Tanaka, Y., Tominari, T., Takatoya, M., Arai, D., Sugasaki, M., Ichimaru, R., Miyaura, C., Matsumoto, C., Ma, S., Suzuki, K., Hirata, M., Grundler, F.M.W., Inada, M. Lutein maintains bone mass in vitro and in vivo against disuse-induced bone loss in hindlimb-unloaded mice. Nutrients 16:4271, 2024
• Karouji, K., Tominari, T., Abe, R., Sugasaki, M., Ikeda, K., Matsumoto, C., Miyaura, C., Miyata, S., Nomura, Y., Itoh, Y., Hirata, M., Inada, M. Loss of ERα involved-HER2 induction mediated by the FOXO3a signaling pathway in fulvestrant-resistant breast cancer. Biochemical and Biophysical Research Communication (Biochem. Biophys. Res. Commun.) 742:151056, 2025
• Kelly, H., Inada, M., Itoh, Y. The diverse pathways for cell surface MT1-MMP localization in migratory cells. Cells 14: 209, 2025
• Tominari T, Matsumoto C, Tanaka Y, Shimizu K, Takatoya M, Sugasaki M, Karouji K, Kasuga U, Miyaura C, Miyata S, Itoh Y, Hirata M, Inada M, Roles of Toll-like Receptor Signaling in Inflammatory Bone Resorption. BIOLOGY-BASEL, 2024 13:692. doi: 10.3390/biology13090692.
• Urano K, Tanaka Y, Tominari T, Takayoya M, Arai D, Miyata S, Matsumoto C, Miyaura C, Numabe Y, Itoh Y, Hirata M and Inada M, The stiffness and collagen control differentiation of osteoclasts with an altered expression of c-Src in podosome. Biochemical and Biophysical Research Communication (B.B.R.C.) vol704, 149636 (2024)
• Tominari T., Takatoya M., Matsubara T, Matsunobe M., Arai D., Matsumoto C., Hirata M., Yoshinouchi S., Miyaura C., Itoh Y., Komaki H., Takeda S., Aoki Y., InadaM., Establishment of a quantitation method using triple quadrupole HPLC-MS quantitation method for dystrophin protein in mouse and human skeletal muscle. International Journal of Molecular Sciences (Int. J. Mol. Sci.) 2024, 25(1), 303.
• Yoshinouchi S, Karouji K, Tominari T, Sugasaki M, Matsumoto C, Miyaura C, Hirata M, Itoh Y, Inada M. Prostate cancer expressing membrane-bound TGF-α induces bone formation mediated by the autocrine effect of prostaglandin E2in osteoblasts. Biochemical and Biophysical Research Communications. 2023.12;644:40-48. doi: 10.1016/j.bbrc.2022.11.050.
• Tanaka, R., Yoshinouchi, S., Karouji, K., Tanaka, Y., Tominari, T., Hirata, M., Matsumoto, C., Itoh, Y., Miyaura, C., Inada, M. A mouse model of lung cancer induced via intranasal injection for anti-cancer drug screening and evaluation of pathology. FEBS Open Bio. 2022. 13 (1), 51-59
• Tominari T, Akita M, Matsumoto C, Hirata M, Yoshinouchi S, Tanaka Y, Karouji K, Itoh Y, Maruyama T, Miyaura C, Numabe Y, Inada M. Endosomal TLR3 signaling in stromal osteoblasts induces prostaglandin E2-mediated inflammatory periodontal bone resorption. Journal of Biological Chemistry (J. Biol. Chem.): 298-3, 101603, 2022
• Tominari, T., Sanada, A., Ichimaru, R., Matsumoto, C., Hirata, M., Itoh, Y., Numabe, Y., Miyaura, C., Inada, M. Gram-positive bacteria cell wall-derived lipoteichoic acid induces inflammatory alveolar bone loss through prostaglandin E production in osteoblasts. Scientific Reports (Sci Rep.). (11):13353, 2021
• Itoh Y, Ng M, Wiberg A, Inoue K, Hirata N, Paiva KBS, Ito N, Dzobo K, Sato N, Gifford V, Fujita Y, Inada M, Furniss D. A common SNP risk variant MT1-MMP causative for Dupuytren’s Disease has a specific defect in collagenolytic activity. Matrix Biology, 97, 29-30, 2021
• Aharen I, Habash SS, Gleason C, Inada M, Grundler FM, Elashry A. Heterodera schachtii glutathione peroxidase (HsGPx) is a parasitism protein. Journal of Plant Diseases and Protection. 127.111-118, 2020
• Tominari T, Ichimaru R, Taniguchi K, Yumoto A, Shirakawa M, Matsumoto C, Watanabe K, Hirata M, Itoh Y, Shiba D, Miyaura C, Inada M. Hypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice. Scientific reports. 9(1):6614, 2019
• Hirata N , Ichimaru R , Tominari T , Matsumoto C, Watanabe K ,Taniguchi K , Hirata M , Ma S, Suzuki K , Grundler FM , Miyaura C, Inada M. Beta-Cryptoxanthin Inhibits Lipopolysaccharide-Induced Osteoclast Differentiation and Bone Resorption via the Suppression of Inhibitor of NF-B Kinase Activity. Nutrients. 11.2.368
• Aizawa M, Watanabe K, Tominari T, Matsumoto C, Hirata M, Grundler FM, Inada M, Miyaura C. Low Molecular-Weight Curdlan, (1 -> 3)-beta-Glucan Suppresses TLR2-Induced RANKL-Dependent Bone Resorption. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) . 41:1282-1285, 2018