MURAOKA Takahiro

Professional Career

Apr 1, 2004 – Ma. 31, 2007 : JSPS Researcher (Young Scientists Fellowship)
Jul 6, 2006 – Apr 30, 2008 : Visiting Scholar, Northwestern Univ (Stupp Lab).
Apr 1, 2007 – Apr 30, 2008 : JSPS Researcher (Research Fellowship for Young Scientists)
May 1, 2008 – Apr 30,2015 : Assistant Professor, Tohoku Univ., Institute of Multidisciplinary Research for Advanced Materials
Oct 1, 2013 – Mar 31, 2017 : JST PRESTO Researcher
May 1, 2015 – Jan 31, 2017 : Assistant Professor, Tokyo Inst. of Technology, School of Life Science and Technology
Feb 1, 2017 – Nov 30, 2020 : Associate Professor (PI), Tokyo University of Agriculture and Technology, Graduate School of Engineering
Dec 1, 2020 – Present : Professor (PI), Tokyo University of Agriculture and Technology, Institute of Global Innovation Research
Apr. 1, 2021 – Present : KISTEC Researcher

Academic Degrees

Mar. 31, 2004 : Ms. C. in Engineering, The University of Tokyo
Mar. 31, 2007 : Ph. D in Engineering, The University of Tokyo,

Research Interests

Organic Synthesis, Supramolecular Chemistry, Protein Folding, Photoresponsive Molecules, Amphiphiles, Liposome, Ion Channels, Molecular Machines, Peptides

Publications

• Lee, Y. H., Saio, T., Watabe, M., Matsusaki, M., Kanemura, S., Lin, Y., Mannen, T., Kuramochi, T., Kamada, Y., Iuchi, K., Tajiri, M., Suzuki, K., Li, Y., Heo, Y., Ishii, K., Arai, K., Ban, K., Hashimoto, M., Oshita, S., Ninagawa, S., Hattori, Y., Kumeta, H., Takeuchi, A., Kajimoto, S., Abe, H., Mori, E., Muraoka, T., Nakabayashi, T., Akashi, S., Okiyoneda, T., Vendruscolo, M., Inaba, K., and Okumura, M. Ca²⁺-driven PDIA6 biomolecular condensation ensures proinsulin folding. Nature Cell Biology (Nat. Cell Biol.), 2025, https://doi.org/10.1038/s41556-025-01794-8.
• Mori, K., Kuramochi, T., Matsusaki, M., Hashiguchi, Y., Okumura, M., Saio, T., Furukawa, Y., Arai, K., and Muraoka, T. Metal-responsive up-regulation of bifunctional disulfides for suppressing protein misfolding and promoting oxidative folding. Angewandte Chemie International Edition (Angew. Chem. Int. Ed.) 64, e202502187, 2025.
• Yaguchi, A., Uchida, N., Miura, D., Watanabe, G., Hiramatsu, H., Ajioka, I., Matsubara, T., Sato, T., Enkhzaya, C., Itani, S., Saito, T., and Muraoka, T. A photoresponsive hybrid of viruses and supramolecular peptide fibers for multidimensional control of patterning and infection. Angewandte Chemie International Edition (Angew. Chem. Int. Ed.) 64, e202508528, 2025.
• T. Nakayama, A. K. Singh, T. Fukutomi, N. Uchida, Y. Terao, H. Hamada, T. Muraoka, E. Muthusamy, T. K. Kundu, K. Akagawa，Activator of KAT3 Histone Acetyltransferase Family Ameliorates a Neurodevelopmental Disorder Phenotype in the Syntaxin 1A Ablated Mouse Model, CELL REPORTS. 2024, 43, 114101.
• Y. Hara, K. Yoshizawa, A. Yaguchi, H. Hiramatsu, N. Uchida, T. Muraoka, ROS-Responsive Methionine-Containing Amphiphilic Peptides Impart Enzyme-Triggered Phase Transition and Antioxidant Cell Protection. BIOMACROMOLECULES, 2024, 25, 3499.
• Yoshika Hara, Atsuya Yaguchi, Hirotsugu Hiramatsu, and Takahiro Muraoka,. ROS-Triggered Gel–Sol Transition and Kinetics-Controlled Cargo Release by Methionine-Containing Peptides, ChemBioChem,2023, doi: 10.1002/cbic.202200798
• Y. Ohno, C. Nakajima, I. Ajioka, T. Muraoka, A. Yaguchi, T. Fujioka, S. Akimoto, M. Matsuo, A. Lotfy, S. Nakamura, V. Herranz-Pérezg, J. M. García-Verdugog, N. Matsukaw, N. Kaneko, K. Sawamoto, Amphiphilic peptide-tagged N-cadherin forms radial glial-like fibers that enhance neuronal migration in injured brain and promote sensorimotor recovery. Biomaterials, 2023, 294, 122003