メニュー

Enter a search word

Makoto Shibutani

Position

Professor

Affiliations

Division of Animal Life Science, Institute of Agriculture
Life Science - Ikebukuro Team, Institute of Global Innovation Research

Researcher ID

C-2510-2013

0000-0003-3417-9697

Professional Career

2012/10/01 - present : Profesosr, Cooperative Dept. of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
2012/10/01 - present : Professor, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology

Academic Degrees

1989 Ph.D in Medical Science, Tokyo Medical and Dental University

Research Interests

Chemical toxicity, Chemical carcinogenesis, Developmental neurotoxicity, Experimental pathology

Publications

  • Elbadawy M, Kato Y, Saito N, Hayashi K, Abugomaa A, Kobayashi M, Yoshida T, Shibutani M, Kaneda M, Yamawaki H, Mizutani T, Lim CK, Saijo M, Sasaki K, Usui T, Omatsu T. Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-Associated Viruses, SARS-CoV-2 and Pteropine Orthoreovirus. Int J Mol Sci. 2021 Oct 5;22(19):10763
  • Shimizu, S., Maeda, N., Takahashi, Y., Uomoto, S., Takesue, K., Ojiro, R., Tang, Q., Ozawa, S., Okano, H., Takashima, K., Woo, G.H., Yoshida, T., Shibutani, M.: Oral exposure to aluminum chloride for 28 days suppresses neural stem cell proliferation and increases mature granule cells in adult hippocampal neurogenesis of young-adult rats. J. Appl.Toxicol., doi: 10.1002/jat.4299, FEB 2022
  • Kobayashi, M., Yamashita, R., Ichikawa, R., Shibutani, M., Yoshida, T. (2022). Ectopically Localized Epithelial Cell Clumps in Ulcers Are Derived from Reserved Crypt Stem Cells in a Mouse Model of Ulcerative Colitis. Dig. Dis. Sci., doi: 10.1007/s10620-021-07340-4,
  • Ojiro, R., Watanabe, Y., Okano, H., Takahashi, Y., Takashima, K., Tang, Q., Ozawa, S., Saito, F., Akahori, Y., Jin, M., Yoshida, T., Shibutani, M.: Gene expression profiles of multiple brain regions in rats differ between developmental and postpubertal exposure to valproic acid. J. Appl. Toxicol, DOI: 10.1002/jat.4263, 2021
  • Elbadawy M, Kato Y, Saito N, Hayashi K, Abugomaa A, Kobayashi M, Yoshida T, Shibutani M, Kaneda M, Yamawaki H, Mizutani T, Lim C-K, Saijo M, Sasaki K, Usui T, Omatsu T. Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-associated Viruses, SARS-CoV-2 and Pteropine orthoreovirus. International Journal of Molecular Sciences, 22 (19) 10763, 2021
  • Yamashita, R., Yoshida, T., Kobayashi, M., Uomoto, S., Shimizu, S., Takesue, K., Maeda, N., Hara, E., Ohshima, K., Zeng, W., Takahashi, Y., Ikeuchi, A., Okamoto, E., Sugiyama, T., Nagakubo, H., Ichikawa-Seki, M., Shibutani, M.: Leptospiral meningoencephalitis in a raccoon dog. Journal of Veterinary Diagnostic Investigation, 33(6), 1137-1141,2021
  • Takahashi, Y., Yamashita, R., Okano, H., Takashima, K., Ogawa, B., Ojiro, R., Tang, Q., Ozawa, S., Woo, G. H., Yoshida, T., Shibutani, M.: Aberrant neurogenesis and late onset suppression of synaptic plasticity as well as sustained neuroinflammation in the hippocampal dentate gyrus after developmental exposure to ethanol in rats. Toxicology, 462 (2021) 152958, 2021. https://doi.org/10.1016/j.tox.2021.152958
  • Elbadawy, M., Hayashi, K., Ayame, H., Ishihara, Y., Abugomaa, A., Shibutani, M., Hayashi, S. M., Hazama, S., Takenouchi, H., Nakajima, M., Tsunedomi, R., Suzuki, N., Nagano, H., Shinohara, Y., Kaneda, M., Yamawaki, H., Usui, T., Sasaki, K.: Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids. Biomed. Pharmacother. 142, 112043, 2021. https://doi.org/10.1016/j.biopha.2021.112043
  • Takashima, K., Nakajima, K., Shimizu, S., Ojiro, R., Tang, Q., Okano, H., Takahashi, Y., Ozawa,S., Jin, M., Yoshinari, T., Yoshida, T., Sugita-Konishi, Y., Shibutani, M.: Disruption of postnatal neurogenesis and adult-stage suppression of synaptic plasticity in the hippocampal dentate gyrus after developmental exposure to sterigmatocystin in rats. Toxicol. Lett. 349: 69–83, 2021.
  • Eguchi, A., Mizukami, S., Nakamura, M., Masuda, S., Murayama, H., Kawashima., M., Inohana, M., Nagahara, R., Kobayashi, M., Yamashita., R., Uomoto, S., Makino, E., Ohtsuka, R., Takahashi, N., Hayashi, S.-M., Maronpot, R.R., Shibutani, M., Yoshida, T.: Metronidazole enhances steatosis-related early-stage hepatocarcinogenesis in high fat diet-fed rats through DNA double-strand breaks and modulation of autophagy. Environ. Sci. Pollut. Res. Int. . https://doi.org/10.1007/s11356-021-15689-2
  • Shimizu, S., Okada, R., Itahashi, M., Imaoka, M., Woo, G-H., Yoshida, T., Shibutani, M.: Ectopic splenic adenocarcinoma in a dog. J. Comp. Pathol. 187: 2–6, 2021.
  • Elbadawy, M., Sato, Y., Mori, T., Goto, Y., Hayashi, K., Yamanaka, M., Azakami, D., Uchide, T., Fukushima, R., Yoshida, T., Shibutani, M., Kobayashi, M., Shinohara, Y., Abugomaa, A., Kaneda, M., Yamawaki, H., Usui, T., Sasaki, K.: Anti-tumor effect of trametinib in bladder cancer organoid and the underlying mechanism. Cancer Biol. Ther. 22(5-6), 357–371, 2021. https://doi.org/10.1080/15384047.2021.1919004
  • Yamashita, R., Takahashi, Y., Takashima, K., Okano, H., Ojiro, R., Tang, Q., Kikuchi, S., Kobayashi, M., Ogawa, B., Jin, M., Kubota, R., Ikarashi, Y., Yoshida, T., Shibutani, M.: Induction of cellular senescence as a late effect and BDNF-TrkB signaling-mediated ameliorating effect on disruption of hippocampal neurogenesis after developmental exposure to lead acetate in rats. Toxicology 456: 152782, 2021.
  • Okano, H., Okamura, T., Takahashi, Y., Takashima, K., Ojiro, R., Tang, Q., Jin, M., Kikuchi, S., Ogawa, B., Yoshida, T., Yoshinari, T., Shibutani, M., A 28-day repeated oral dose toxicity study of enniatin complex in mice. The Journal of Toxicological Sciences, 46, 4, 157-165, 2021
  • Ideta-Otsuka, M., Miyai, M., Yamamoto, N., Tsuchimoto, A., Tamura, H., Tanemura, K., Shibutani, M., Igarashi, K: Development of a new in vitro assay system for evaluating the effects of chemicals on DNA methylation. The Journal of Toxicological Sciences, 46(2): 83–90, 2021. DOI: 10.2131/jts.46.83
  • Masubuchi, Y., Nakahara, J., Kikuchi, S., Okano, H., Takahashi, Y., Takashima, K., Koyanagi, M., Maronpot, R.R., Yoshida, T., Hayashi, S-M., Shibutani, M., Continuous exposure to a-glycosyl isoquercitrin from developmental stages to adulthood is necessary for facilitating fear extinction learning in rats, Journal of Toxicologic Pathology, 33(4), 247-263, 2020. DOI: 10.1293/tox.2020-0025
  • Nakahara, J., Masubuchi, Y., Takashima, K., Takahashi, Y., Ichikawa, R., Nakao, T., Koyanagi, M., Maronpot, R.R., Yoshida, T., Hayashi, S., Shibutani, M., Continuous exposure to amorphous curcumin formula facilitates anti-anxiety-like behavior and fear extinction learning in rats, Nutrition Research, 85 (2021): 99-118, 2021. DOI:10.1016/j.nutres.2020.10.007
  • Kikuchi, S., Takahashi, Y., Ojiro, R., Takashima, K., Okano, H., Tang, Q., Woo, G-H., Yoshida, T., Shibutani, M., Identification of gene targets of developmental neurotoxicity focusing on DNA hypermethylation involved in irreversible disruption of hippocampal neurogenesis in rats, Journal of Applied Toxicology, DOI: 10.1002/jat.4089. 2020
  • Bradley, A.E., Bolon, B., Butt, M.T., Cramer, S.D., Czasch, S., Garman, R.H., George, C., Gröters, S., Kaufmann, W., Kovi, R.C., Krinke, G., Little, P., Narama, I., Rao, D.B., Sharma, A.K., Shibutani, M., Sills, R., Proliferative and non-proliferative lesions of the rat and mouse central and peripheral nervous systems: New and revised INHAND terms, Toxicologic Pathology, 0192623320951154、DOI: 10.1177/0192623320951154
  • Abugomaa, A., Elbadawy, M., Yamanaka, M., Goto, Y., Hayashi, K., Mori, T., Uchide, T., Azakami, D., Fukushima, R., Yoshida, T., Shibutani, M., Yamashita, R., Kobayashi, M., Yamawaki, H., Shinohara, Y., Kaneda, M., Usui, T., Sasaki, K., Establishment of 2.5D organoid culture model using 3D bladder cancer organoid culture. Scientific Reports, 10(1), 9393, 2020.
  • Ito, Y., Nakajima, K., Masubuchi, Y., Kikuchi, S., Okano, H., Saito, F., Akahori, Y., Jin, M., Yoshida, T., Shibutani, M., Downregulation of low-density lipoprotein receptor class A domain-containing protein 4 (Ldlrad4) in the liver of rats treated with nongenotoxic hepatocarcinogen to induce transforming growth factor beta signaling promoting cell proliferation and suppressing apoptosis in early hepatocarcinogenesis, Journal of Applied Toxicology, 40 (11), 1467-1479, 2020
  • Elbadawy, M., Yamanaka, M., Goto, Y., Hayashi, K., Tsunedomi, R., Hazama, S., Nagano, H., Yoshida, T., Shibutani, M., Ichikawa, R., Nakahara, J., Omatsu, T., Mizutani, T., Katayama, Y., Shinohara, Y., Abugomaa, A., Kaneda, M., Yamawaki, H., Usui, T., Sasaki, K.: Efficacy of primary liver organoid culture from different stages of non-alcoholic steatohepatitis (NASH) mouse model. Biomaterials 237:119823, 2020
  • Nakajima, K., Ito, Y., Kikuchi S., Okano, H., Takashima, T., Woo, G.-H., Yoshida, T., Yoshinari T., , Sugita-Konishi, Y., Shibutani, M., Developmental Exposure to Diacetoxyscirpenol Reversibly Disrupts Hippocampal Neurogenesis by Inducing Oxidative Cellular Injury and Suppressed Differentiation of Granule Cell Lineages in Mice. Food Chemical Toxicology (Food Chem Toxicol.), 136, 111046, 2020.
  • Ito, Y., Nakajima, K., Masubuch, Y., Kikuchi, S., Saito, F., Akahori, Y., Jin, M., Yoshida, T., Shibutani, M.: Differential responses on energy metabolic pathway reprogramming between genotoxic and non-genotoxic hepatocarcinogens in rat liver cells. Journal of Toxicologic Pathology (J. Toxicol. Pathol.) 32 (4), 261-274, 2019
  • Tanaka, T., Masubuchi, Y., Okada, R., Nakajima, K., Nakamura, K., Masuda, S., Nakahara, J., Maronpot, R.R., Yoshida, T., Koyanagi, M., Hayashi, S.M., Shibutani, M. Ameliorating effect of postweaning exposure to antioxidant on disruption of hippocampal neurogenesis induced by developmental hypothyroidism in rats. Journal of Toxicological Sciences (J. Toxicol. Sci.). 44(5), 357-372, 2019
  • Masubuchi, Y., Tanaka, T., Okada, R., Ito, Y., Nakahara, J., Kikuchi, S., Watanabe ,Y., Yoshida, T., Maronpot,,R.R., Koyanagi, M., Hayashi, S.M., Shibutani, M. Lack of preventive effect of maternal exposure to alpha-glycosyl isoquercitrin and alpha-lipoic acid on developmental hypothyroidism-induced aberrations of hippocampal neurogenesis in rat offspring.  Journal of Toxicologic Pathology(J. Toxicol. Pathol.). 32(3), 165-180, 2019 .
  • Watanabe, Y., Nakajima, K., Ito, Y., Akahori, Y., Saito, F., Woo, G.H., Yoshida, T., Shibutani, M. Twenty-eight-day repeated oral doses of sodium valproic acid increases neural stem cells and suppresses differentiation of granule cell lineages in adult hippocampal neurogenesis of postpubertal rats. Toxicology Letter (Toxico.l Lett.). 312, 195-203, 2019
  • Ito, N., Yoshida, T., Ichikawa, R., Makino, E., Akema, S., Fukumori, J., Takahashi, N., Nakahara, J., Yamashita, R., Orihara, K., Kobayashi, M., Xiantao, H., Watanabe, Y., Mizukami, S., Shibutani, M. Clinical and pathological characteristics of acute myelogenous leukemia in a female koala with diabetes mellitus, Journal of Veterinary Medical Science (J. Vet. Med. Sci.). 81(8), 1229-1233, 2019.
  • Elbadawy, M., Usui, T., Mori, T., Tsunedomi, R., Hazama, S., Nabeta, R., Uchide, T., Fukushima, R., Yoshida, T., Shibutani, M., Tanaka, T., Masuda, S., Okada, R., Ichikawa, R., Omatsu, T., Mizutani, T., Katayama, Y., Noguchi, S., Iwai, S., Nakagawa, T., Shinohara, Y., Kaneda, M., Yamawaki, H., Sasaki, K. Establishment of a novel experimental model for muscle-invasive bladder cancer using a dog bladder cancer organoid culture. Cancer Science (Cancer Sci.). 110(9):2806-2821, 2019.
  • Ito, Y., Nakajima, K., Masubuchi, Y., Kikuchi, S., Saito, F., Akahori, Y., Jin, M., Yoshida, T., Shibutani, M.: Expression Characteristics of Genes Hypermethylated and Downregulated in Rat Liver Specific to Nongenotoxic Hepatocarcinogens. Toxicological Sciences (Toxicol. Sci.) 169(1): 122–136, 2019
  • Okada, R., Masubuchi, Y., Tanaka, T., Nakajima, K., Masuda, S., Namamura, K., Maronpot, R.R., Yoshida, T., Koyanagi, M., Hayashi, S-M., Shibutani, M.: Continuous exposure to alpha-glycosyl isoquercitrin from developmental stage facilitates fear extinction learning in rats. Journal of Functional Foods (J. Funct. Foods) 55(2019): 312–324, 2019
  • Nakajima, K., Tanaka, T., Masubuchi, Y., Ito, Y., Kikuchi, S., Woo, G-H., Yoshida, T., Shibutani, M.: Developmental exposure of mice to T-2 toxin increases astrocytes and hippocampal neural stem cells expressing metallothionein. Neurotoxicity Research (Neurotox. Res.) 35(3): 668–683, 2019
  • Tanaka, T., Nakajima, K., Masubuchi, Y., Ito, Y., Kikuchi, S., Ideta-Ohtsuka, M., Woo, G-H., Yoshida, T., Igarashi, K., Shibutani, M.: Aberrant epigenetic gene regulation in hippocampal neurogenesis of mouse offspring following maternal exposure to 3,3’-iminodipropionitrile. The Journal of Toxicological Sciences (J. Toxicol. Sci.) 44(2): 93–105, 2019.

このページの上部へ