NAGASAWA Kazuo

Professional Career

1993.04 - 2000.12 : Researcher, RIKEN
2001.01 - 2004.03 : Assistant Professor, Institute of Molecular and Cellular Biosciences, The University of Tokyo
2004.04- 2009.03 : Assistant Professor, Institute of Engineering, Tokyo University of Agriculture and Technology
2009.04- present : Professor, Institute of Engineering, Tokyo University of Agriculture and Technology

Academic Degrees

1993　Ph.D. in Engineering, Waseda University

Research Interests

Natural organic Compounds, Guanidine, Vitamin D, Bone, Organocatalyst, Teromelase, Ion channel

Publications

• Tu, A.T.T., Hoshi, K., Ma, Y., Oyama, T., Suzuki, S., Tsukakoshi, K., Nagasawa, K., Ikebukuro, K. & Yamazaki, T., Effects of G-Quadruplex Ligands on the Topology, Stability, and Immunostimulatory Properties of G-Quadruplex-Based CpG Oligodeoxynucleotides. ACS Chem Biol 17, 1703-1713 (2022)
• Pokhrel, P., Sasaki, S., Hu, C., Karna, D., Pandey, S., Ma, Y., Nagasawa, K., Mao, H. Single-molecule displacement assay reveals strong binding of polyvalent dendrimer ligands to telomeric G-quadruplex. Anal. Biochem., 649, Article number: 114693, 2022.
• Kaufmann M, Schlingmann K-P, Berezin L, Molin A, Sheftel J, Vig M, Gallagher GC, Nagata A, Masoud SS, Sakamoto R, Nagasawa K, Uesugi M, Kottler ML, Konrad M, Jones G, Differential diagnosis of vitamin D-related hypercalcemia using serum vitamin D metabolite profiling, J. Bone Miner. Res. 36, 1340-1350, DOI: 10.1002/jbmr.4306. 2021.
• Yasuda, M., Ma, Y., Okabe, S., Wakabayashi, Y., Su, D., Chang, Y.-T., Seimiya, H., Tera, M., Nagasawa, K., Target identification of a macrocyclic hexaoxazole G-quadruplex ligand using post-target-binding visualization, Chemical communication (Chem. Commun.), 56, 12905-12908 (2020)
• Reinicke, J., Kitatani, R., Sedghi Masoud, S., Kawabata Galbraith, K., Yoshida, W., Igarashi, A., Nagasawa, K., Berger, G., Yanagihara, A., Nagai, F. A., Horgen, A. Isolation, Structure Determination, and Synthesis of Cyclic Tetraglutamic Acids from Box Jellyfish Species Alatina alata and Chironex yamaguchii. Molecules, 25, Article number:883, 2020
• Maleki, P., Mustafa, G., Gyawali, P., Budhathoki, J., Ma, Y., Nagasawa, K., Balci, H. Quantifying the impact of small molecule ligands on G-quadruplex stability against Bloom helicase. Nucleic Acids Research (Nucl. Acids Res.). 2019, 47 (20), 10744-10753, 2019.
• Gyawali, P., Gc, K., Ma, Y., Abeysirigunawardene, S., Nagasawa, K., Balci, B. Impact of Small Molecules on Intermolecular G-quadruplex Formation. Molecules. 24, Article number:1570. 2019.
• Jonchhe, S., Ghimire, C., Cui, Y., Sasaki, S., Park, S., Iida, K., Nagasawa, K., Sugiyama, H., Mao, H. Binding of a Telomestatin Derivative Changes Mechanical Anisotropy of Human Telomeric G-quadruplex, Angew. Chem., Int. Ed. 2019, 58, 877-881.
• Ma, Y., Iida, K., Sasaki, S., Hirokawa, T., Brahim, H., Phan, A.-T., Nagasawa, K. Synthesis and Telomeric G-quadruplex-stabilizing Ability of Macrocyclic Hexaoxazoles bearing Three Side Chains, Molecules 2019, 24, Article number:263. DOI: 10.3390/molecules24020263.
• Punnoose, A., Ma, Y., Enamul Hoque, M., Cui, Y., Sasaki, S., Huixin Guo, A., Nagasawa, K., Mao, H. Random Formation of G-Quadruplexes in the Full-Length Human Telomere Overhangs Leads to a Kinetic Folding Pattern with Targetable Vacant G-Tracts. Biochemistry, 57: 6946-6955, 2018.
• Mustafa, G., Chuang, C.-Y., Roy, A. W., Farhath, M. M., Pokhrel, N., Ma, Y., Nagasawa, K., Antony, E., Comstock, M. J., Basu, S., Balci, H. A Force Sensor that Converts Fluorescence Signal into Force Measurement Utilizing Short Looped DNA. Biosens Bioelectron. 2018, 121:34-40
• Sedghi, S. M., Yamaoki, Y., Ma, Y., Marchand, A., Richtia, A. F., Gabelica, V., Phan, A. T., Katahira, M., Nagasawa, K. Analysis of interaction between telomeric i-motif DNA and a cyclic tetraoxazole compound . ChemBioChem. 2018, 19:21:2268-2272, DOI: 10.1002/cbic.201800425