Event
【GIR Open Seminar】 Dr. Guanghui Ma / University of Chinese Academy of Sciences (China)
| Date | 2025.3.24 (16：30 - 18：00) |
|---|---|
| Venue |
Meeting ID:896 9788 8682 Passcode:747809 |
| Speaker | Dr. Guanghui Ma |
| Affiliation | University of Chinese Academy of Sciences (China) |
| Title | "Novel Particle with Special Morphology: Design and Application in Vaccine Delivery" ＜Abstract＞ We have proposed a strategy to use a particle as a chassis, and then assemble antigen and other components on/in it to form a synthetic biomimetic vaccine. Particle can mimic the size and properties of pathogen. In this talk, we designed the particles with interesting morphology as the chassis to prepare synthetic vaccines. 1) We used nanoparticles instead of emulsifier to stabilize squalene oil to obtain Pickering emulsion, and then assembled antigen on the surface to form biomimetic vaccine. We found that Pickering emulsion chassis can mimic rough surface, deformability (pliability) and antigen mobility of pathogen. As a result, the vaccines showed excellent preventive effect and therapeutic effect. 2) We proposed to use a self-healing hollow particle (porous particle) as a chassis for inhaled vaccine. The large pores allowed easy encapsulation of nano-vaccine. And the micro-sized particle allowed efficient deposition of vaccine in lung. This micro-nano structured vaccine provided excellent systemic and mucosal immune response. |
| Language | English |
| Intended for | Everyone is welcome to join. |
| Co-Organized by | Institute of Global Innovation Research, "Food" Kajita Team Excellent Leader Development for Super Smart Society by New Industry Creation and Diversity |
| Contact | Institute of Global Innovation Research, Institute of Engineering Prof. Kenji Ogino Email: kogino (at) cc.tuat.ac.jp |
| Remarks | This seminar will be held both face-to-face and online concurrently. |
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