Event
【GIR Open Seminar】 Dr. Takeshi Harayama / Institut de Pharmacologie Moléculaire et Cellulaire – CNRS, Université Côte d’Azur (France)
| Date | 2024.11.29 (17：00 - 18：00) |
|---|---|
| Venue |
Conference Room L0811, 1st Fl., Building 8, Koganei Campus, TUAT |
| Speaker | Dr. Takeshi Harayama |
| Affiliation | Institut de Pharmacologie Moléculaire et Cellulaire - CNRS, Université Côte d'Azur (France) |
| Title | "Connecting lipid tail structures to cellular functions" ＜Abstract＞ Cellular membranes are composed of a diverse set of lipids with tails that vary significantly in chain lengths, the number of double bonds and the positions of these double bonds. Although lipids with uniform tails are sufficient to make bilayers in vitro, the diversity in lipid tail structures is seen across the tree of life, suggesting the biological importance of having lipids with distinct tails. It is critical to decode the functional relevance of lipid tails to understand the basic architecture of our cells, and to correctly assess the importance of lipidome changes that are seen in various diseases. For this, we are developing tools that combine genetics and synthetic lipid feeding to manipulate the tail composition of membrane lipids in cells, allowing us to study their consequences. In this seminar, I will discuss how an optimal combination of lipid head groups and tails is generated in cells, and how they contribute to cellular processes, such as ferroptosis, which is a lipid peroxidation-dependent cell death. |
| Language | English |
| Intended for | Everyone is welcome to join. |
| Co-Organized by | Institute of Global Innovation Research, "Life Science" Kawano Team Excellent Leader Development for Super Smart Society by New Industry Creation and Diversity |
| Contact | Institute of Global Innovation Research, Institute of Engineering Prof. Hiroshi Tsugawa Email: htsugawa(at) go.tuat.ac.jp |
| Remarks | This seminar will only be held face-to-face. |
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