【GIR Open Seminar】Dr. Ikuo Masuho / Sanford Research (U.S.A.)

Date	2024.6.6 (16：00 - 17：00)
Venue	Lecture Room L1342, 4F., Building 13, Koganei Campus, TUAT
Speaker	Dr. Ikuo Masuho
Affiliation	Sanford Research (U.S.A.)
Title	"The Ghrelin Receptor: Bridging Structure and Therapy" ＜Abstract＞ This study explores the mechanism behind anamorelin, the only approved drug targeting the ghrelin receptor, in comparison to other synthetic drugs, focusing on its superagonistic activity. Our findings reveal how different ligands bind to the receptor, inducing various conformations and influencing signal transduction. Additionally, we demonstrate the importance of structural data in identifying genetic variations that affect drug efficacy, thereby improving the selection of therapeutics based on individual genetic profiles. This research advances the use of structural analysis for optimizing ghrelin receptor-targeted therapies.
Language	English
Intended for	Everyone is welcome to join.
Co-Organized by	Institute of Global Innovation Research ”LIFE SCIENCE” Fukutani Team Excellent Leader Development for Super Smart Society by New Industry Creation and Diversity
Contact	Institute of Global Innovation Research, Institute of Engineering Asst. Prof. Yosuke Fukutani e-mail: fukutani@cc.tuat.ac.jp
Remarks	This seminar will only be held face-to-face.

Event