【GIR Open Seminar】 Dr. Yoshifumi Itoh / University of Oxford (U.K.)

Date	2023.12.21 (16：00 - 17：00)
Venue	Lecture Room L0631, 3F., Building 6, Koganei Campus, TUAT
Speaker	Dr. Yoshifumi Itoh
Affiliation	University of Oxford (U.K.)
Title	"Posttranslational regulation of cell surface proteinase: crucial events for cell migration and invasion" ＜Abstract＞ One of the cell surface proteinases, MT1-MMP, promotes invasion of various cell types, including cancer cells, fibroblasts, endothelial cells, and macrophages. Usually, proteolytic enzymes are tightly regulated in vivo by their gene expression, activation of the zymogen, and inhibition by endogenous inhibitors. However, recent findings suggest that MT1-MMP further requires various post-translational regulation, allowing the control of the MT1-MMP activity during cell invasion dynamically. Using this knowledge, novel means to regulate unwanted cellular invasion can be developed.
Language	English
Intended for	Everyone is welcome to join.
Co-Organized by	Institute of Global Innovation Research, "Life Science" Inada Team Excellent Leader Development for Super Smart Society by New Industry Creation and Diversity
Contact	Institute of Global Innovation Research, Institute of Engineering Assoc. Prof. Masaki Inada Email: inada(at)cc.tuat.ac.jp

Event