Event
【GIR Open Seminar】 Dr. Mauro Rossi / National Research Council of Italy (Italy)
| Date | 2023.5.11 (16：30 - 17：30) |
|---|---|
| Venue |
Lecture Room 1-11, 1st Fl., Building 1, Fuchu Campus, TUAT Meeting ID:873 0347 0456 Passcode:Vw98E0 |
| Speaker | Dr. Mauro Rossi |
| Affiliation | National Research Council of Italy (Italy) |
| Title | "High fat diet-wheat gliadin interaction and its implication for Obesity and Celiac Disease onset: in vivo studies" ＜Abstract＞ The intestinal immune system may play a crucial role in obesity and insulin resistance. An altered intestinal immunity is associated with changes to the gut microbiota, barrier function and tolerance to luminal antigens. Lipid metabolism and its unbalance can also contribute to acute and chronic inflammation in different conditions. In Celiac disease (CD), the serum phospholipid profile in infants who developed CD was dramatically different when compared to that of infants at risk of CD not developing the disease. In HLA-DQ8 transgenic mice, a model of gluten sensitivity, we demonstrated that oral wheat gliadin challenge, in connection with inhibition of the metabolism of arachidonic acid, an omega-6 polyunsaturated fatty acid, specifically induces the enteropathy. Recent evidences suggest that gluten may play a role also for development of life-style related diseases in populations on a high fat diet (HFD). However, the mechanisms behind these effects are not yet understood. Exploratory studies in mice fed HFD showed that wheat gliadin consumption affected glucose and lipid metabolic homeostasis, altered the gut microbiota, and altered the immune cell composition of liver. |
| Language | English |
| Intended for | Everyone is welcome to join. |
| Co-Organized by | Institute of Global Innovation Research, "Life Science" Kawano Team Excellent Leader Development for Super Smart Society by New Industry Creation and Diversity |
| Contact | Institute of Global Innovation Research Assoc. Prof. Junki Miyamoto Email: m-junki (at) go.tuat.ac.jp |
| Remarks | This seminar will be held both face-to-face and online concurrently. |
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