Event
【GIR Open Seminar】 Dr. Takeshi Harayama / Institut de Pharmacologie Moléculaire et Cellulaire – CNRS, Université Côte d’Azur (France)
| Date | 2023.3.8 (17：00 - 18：00) |
|---|---|
| Venue |
Lecture Room L0811, 1st. Fl., Building 8, Koganei Campus, TUAT Meeting ID:867 8775 7914 Passcode:279194 |
| Speaker | Dr. Takeshi Harayama |
| Affiliation | Institut de Pharmacologie Moléculaire et Cellulaire - CNRS, Université Côte d'Azur (France) |
| Title | "Delineating the roles of lipid structures through metabolic manipulation of cells" ＜Abstract＞ Cellular membranes contain hundreds, if not thousands, of distinct lipid species. However, the current understanding about the relationship between lipid structures and functions remains severely limited. To overcome this, we are engineering cultured cells to manipulate their metabolism and alter their lipid composition. We use a highly efficient CRISPR-Cas9 approach to delete lipid metabolic genes in a multiplex manner, and combine it with lipidomics analyses to generate cells with altered lipid structures. With this, we found that the presence of very long-chain fatty acids in sphingolipids is critical to maintain overall membrane lipid composition of cells. In addition, we discovered the mechanism how cells accumulate polyunsaturated fatty acids at the inner leaflet of the plasma membrane, and found that this regulation is critical for ferroptotic cell death. |
| Language | English |
| Intended for | Everyone is welcome to join. |
| Co-Organized by | Institute of Global Innovation Research, "Life Science" Kawano Team Excellent Leader Development for Super Smart Society by New Industry Creation and Diversity |
| Contact | Institute of Global Innovation Research, Institute of Engineering Assoc. Prof. Hiroshi Tsugawa Email: htsugawa(at) go.tuat.ac.jp |
| Remarks | This seminar will be held both face-to-face and online concurrently. |
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