【GIR Open Seminar】Dr. Yoshifumi Itoh / University of Oxford (U.K.)

Date	2022.12.15 (16：00 - 17：00)
Venue	Lecture Room 1153, 5th Fl., Bldg. 11, Koganei Campus, TUAT
Speaker	Dr. Yoshifumi Itoh
Affiliation	University of Oxford (U.K.)
Title	◆"MT1-MMP: a major player in tissue homeostasis, tissue destruction, and cellular invasion " ＜Abstract＞ Fibrillar collagen is a major structural protein in mammals, and its tissue levels are tightly regulated by its production and proteolytic degradation. If the production exceeds, tissue fibrosis will occur; if the degradation exceeds, tissue architecture will be destroyed. There are five collagen-degrading enzymes under neutral pH in humans, including MMP-1, MMP-2, MMP-8, MMP-13, and MT1-MMP. Among them, MT1-MMP is the only type I transmembrane proteinase, and it degrades collagen and other substrates on the cell surface. Accumulating evidence suggests that MT1-MMP is a crucial enzyme regulating tissue homeostasis, tissue destruction, and cellular invasion in various pathophysiological conditions. In this seminar, the roles and regulations of MT1-MMP in these processes will be discussed.
Language	English
Intended for	Everyone is welcome to join.
Co-Organized by	Institute of Global Innovation “Life Science” Inada Unit Excellent Leader Development for Super Smart Society by New Industry Creation and Diversity
Contact	Institute of Global Innovation Research, Institute of Engineering Assoc. Prof. Masaki Inada e-mail: inada (at) cc.tuat.ac.jp

Event