【GIR Open Seminar】 Dr. Hirotsugu Hiramatsu / National Yang Ming Chiao Tung University (Taiwan)

Date	2022.7.22 (16：45 - 18：00)
Venue	Green Hall, 1st Floor, New Building 1, Koganei Campus, TUAT
Speaker	Dr. Hirotsugu Hiramatsu
Affiliation	National Yang Ming Chiao Tung University (Taiwan)
Title	"Structure analysis of amyloid fibril β-sheets using vibrational spectroscopy" 〈Abstract〉 Amyloid fibril is a needle-like aggregate of proteins. The fibril formation is a well-known self-organization process. This talk focuses on various approaches using vibrational spectroscopy for fibril structure analysis. β2-microglobulin 21-29 fragment (b2m21-29) is studied as it has an interesting property to form the parallel (P) or anti-parallel (AP) β-sheet structures depending on pH. We discuss how to distinguish the Pβ and APβ structures, how to know the location of β-strands in the sequence, how to compare the intermolecular interaction strength, and consider if or not a “mixed β-sheet” of Pβ and APβ" occurs.
Language	English
Intended for	Everyone is welcome to join.
Co-Organized by	Institute of Global Innovation Research, "Life Science" Kawano Team Excellent Leader Development for Super Smart Society by New Industry Creation and Diversity
Contact	Institute of Global Innovation Research, Institute of Engineering Prof. Takahiro Muraoka Email: muraoka (at) go.tuat.ac.jp
Remarks	This seminar will be held onsite only. There will be no video streaming after the presentation.

Event