| Date | 2022.3.9 (10：00 - 12：00) |
|---|---|
| Venue | |
| Speaker | Dr. Andrea C. Gore / Dr. David Crews |
| Affiliation | The University of Texas (U.S.A.) |
| Title | ◆Dr. Andrea C. Gore (Professor, Division of Pharmacology and Toxicology, The University of Texas, U.S.A.) ◆Title : "Endocrine-disrupting chemicals and the neurobiology of social behavior ” 〈Abstract〉 This talk will focus on work conducted on effects EDCs on neuroendocrine systems and the behaviors they regulate. Studies in the Gore Lab have been using a rat model of prenatal exposure to different classes of EDCs. This developmental exposure period includes the critical period of brain sexual differentiation, when natural sex differences in brain circuits become organized, thus making it particularly vulnerable to EDCs. Behavioral work will be presented showing that: 1) prenatal EDC exposures perturb mate preference in adulthood; 2) these rats also show deficits in odor preference that may explain the mate preference phenotype; 3) ultrasonic vocalizations emitted in a sociosexual setting are changed by prenatal EDCs; and 4) EDCs perturb behavior in a social novelty test. Then I will describe work conducted to understand the roles of the oxytocin and vasopressin systems in the PVN and SON, with results demonstrating a series of small but significant differences in the distribution of the nanopeptides and expression of genes related to their signaling. The collective results suggest that EDCs induce changes that, in combination, alter the “essential phenotype” of individuals. ＜Reference＞ ・Reilly MP, Kunkel MN, Thompson LM, Zentay A, Weeks C, Crews D, Cormack LK, Gore AC (2022). Effects of prenatal PCBs on hypothalamic oxytocin and vasopressin systems. Journal of Experimental Zoology Part A 337: 75-87. https://onlinelibrary.wiley.com/doi/10.1002/jez.2475 ・Hernandez Scudder ME, Weinberg A, Thompson L, Crews D, Gore AC (2020) Prenatal EDCs impair mate and odor preference and activation of the VMN in male and female rats. Endocrinology 161: 1-13. https://academic.oup.com/endo/article/doi/10.1210/endocr/bqaa124/5874569?guestAccessKey=192eb929-cd23-4e62-ba66-45a93063ffee ・Hernandez Scudder ME, Kunkel MN, Gore AC (2020) Exposure to prenatal PCBs shifts the timing of neurogenesis in the hypothalamus of developing rats. Journal of Experimental Zoology Part A 333: 550-560. https://onlinelibrary.wiley.com/share/author/9SY5WV4ZAJBWBDMXYYWW?target=10.1002/jez.2404 ・Review article: Gore AC, Krishnan K, Reilly MP (2019) Endocrine-disrupting chemicals: Effects on neuroendocrine systems and the neurobiology of social behavior. Hormones and Behavior 111: 7-22. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30476496/ ◆Dr. David Crews (Professor Emeritus, Section of Integrative Biology, The University of Texas, U.S.A.) ◆Title : "Vertebrate Sexuality” 〈Abstract〉 It is often thought that Sex and the same thing as Sexuality. It is not so. Sex is in the gonads, while Sexuality is in the brain. Research indicates that the determinants of gonadal sex do not dictate Sexuality. |
| Language | English |
| Intended for | Everyone is welcome to join. |
| Co-Organized by | Institute of Global Innovation Research, “FOOD” Watanabe Team Excellent Leader Development for Super Smart Society by New Industry Creation and Diversity |
| Contact | Institute of Global Innovation Research, Institute of Agriculture Prof. Gen Watanabe Email: gen(at)cc.tuat.ac.jp |
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