| Date | 2021.2.19 (10：30 - 12：00) |
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| Venue | |
| Title | Google classroom is now available. 1. Go to https://classroom.google.com and sign in. 2. At the upper right, click 「+」 and click 「join」. 3. Enter the class code gt233hu --------------------------------------------------------------------------- ※On-line Seminar via Zoom and Google Classroom. Join the Zoom Meeting https://tuat-jp.zoom.us/j/88481389515?pwd=aHJHejllVGxmV2VUQ1hjY1pobGRzQT09 Meeting ID: 884 8138 9515 Pass Code: 662157 ---------------------------------------------------------------------------------------------------------- ◆Prof. Andrea C. Gore (Professor, Division of Pharmacology and Toxicology, The University of Texas, USA) ◆Title: "Endocrine disruption of brain and behavior." 〈Abstract〉 Environmental endocrine-disrupting chemicals (EDCs) interfere with hormones and their actions. Exposures to EDCs during critical periods of life, especially in the developing fetus and infant, are particularly problematic due to the high sensitivity of the developing brain to hormones, and the greater potential to be affected by EDCs. Our lab has been using a rat model of prenatal exposure to two classes of EDCs: a polychlorinated biphenyl (PCB) mixture used previously in industry, the fungicide vinclozolin, in current agricultural use. These chemicals are administered to pregnant rats to ascertain effects on the developing offspring. These female and male rats, the F1 generation, are phenotyped for effects on development, hormones and behavior in adulthood, molecular and cellular changes to the brain, and functional behavioral outcomes. The current talk will focus mainly on recent work showing that EDC exposures affect mate preference of F1 female and male rats in adulthood, and the potential neural pathways and mechanisms. As a whole, our work indicates that gestational exposure to PCBs has lifelong effects on the developing brain, neuroendocrine systems, and reproductive and social behaviors in exposed individuals. These data are highly relevant to humans and wildlife, as all individuals are exposed to environmental chemicals due to their persistence and ubiquity. |
| Language | English |
| Intended for | Everyone is welcome to join. |
| Co-Organized by | Institute of Global Innovation Research, “FOOD” Watanabe Team Excellent Leader Development for Super Smart Society by New Industry Creation and Diversity |
| Contact | Institute of Global Innovation Research, Institute of Agriculture Prof. Gen Watanabe Email: gen(at)cc.tuat.ac.jp |
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