【GIR Open Seminar】　Dr. Naoki Yamanaka / University of California, Riverside (U.S.A.)　”Transporter-mediated steroid hormone transport across cell membranes”

Date	2019.12.18 (16：30 - 17：30)
Venue	Lecture Room L1342, Building 13, Koganei Campus, TUAT
Title	◆Dr. Naoki Yamanaka (Assistant Professor, Department of Entomology, University of California, Riverside, U.S.A.) "Transporter-mediated steroid hormone transport across cell membranes" 〈Abstract〉 The insect steroid hormone ecdysone induces molting and metamorphosis through its interaction with intracellular nuclear receptors. Although it has long been assumed that all steroid hormones can enter their target cells by simple diffusion, we recently demonstrated in the fruit fly Drosophila that a membrane transporter named Ecdysone Importer (EcI) is required for cellular uptake of ecdysone (Okamoto et al., Dev Cell 2018). To further explore physiological significance of transporter-mediated steroid hormone entry into cells, we continued our study and found that EcI has a critical role in the blood-brain barrier during Drosophila brain development. I will present our most recent results and discuss the importance of the steroid hormone importer in insect development and beyond.
Language	English
Intended for	Everyone is welcome to attend.
Co-Organized by	Institute of Global Innovation “Life Science” Shinohara Team Excellent Leader Development for Super Smart Society by New Industry Creation and Diversity
Outline	Poster
Contact	Institute of Global Innovation Research, Institute of Engineering Assoc. Prof. Ryuji Kawano e-mail: rjkawano (at) cc.tuat.ac.jp

Event