Promoting Healthy Longevity and a Vibrant Society through a Cross-Organ Understanding of Tissue Homeostasis

• Overview

  As populations age worldwide, the challenge is not simply to live longer, but to remain healthy and active throughout life. Our organs continuously adapt to environmental changes to maintain their functions, yet the mechanisms shared across different organs remain poorly understood. Our research focuses on LRP1, a multifunctional protein that regulates the environment surrounding cells and their responses to external signals. By investigating its roles across the brain, lungs, intestines, bones, and joints, we aim to uncover common principles of tissue homeostasis and understand how these mechanisms break down during ageing and disease. Bringing together multidisciplinary expertise at Tokyo University of Agriculture and Technology and leading international researchers, we seek to move beyond traditional organ-specific research and pioneer a new approach to understanding health and disease. Ultimately, our discoveries could lead to innovative treatments, disease prevention strategies, and health-promoting functional foods, contributing to a society where everyone can live longer, healthier, and more fulfilling lives.

  

Members

MIYATA Shinji (Scleroprotein and Leather Research Institute / Associate Professor)
MIYAMOTO Junki (Institute of Agriculture / Associate Professor)
KOZONO Takuma (Institute of Agriculture / Assistant Professor)
MUKO Ryo (Institute of Global Innovation Research / Assistant Professor)