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Lipid Modalities: Integrative Approaches Combining Metabolomic Profiling and Synthetic Membrane Systems

ARC-Kawano Team

  • Overview

    Lipids are fundamental components of cellular membranes and play essential roles in energy storage and signal transduction. Increasing evidence indicates that interactions between lipids and host-associated microbes, such as gut microbiota, are closely linked to the onset and progression of various diseases, including obesity, diabetes, cardiovascular disorders, inflammatory bowel diseases, and neurological conditions. This project aims to elucidate the molecular mechanisms underlying lipid metabolism and its interplay with gut microbes by integrating bioengineering approaches, thereby advancing our understanding of lipid machinery in biological systems. In parallel, research on artificial cell membranes and synthetic cells seeks to mimic the functions of natural membranes, with the goal of developing novel bio-devices and innovative diagnostic and therapeutic technologies. Special emphasis is placed on the application of nanopore-based techniques in next-generation medical tools.

Team Head

International Researcher(s)

Takanari Inoue

Affiliation Johns Hopkins University (U.S.A.)
Division / Department Department of Cell Biology
Position Professor
URL

https://pages.jh.edu/inouelab/

James Friend

Affiliation University of California, San Diego (U.S.A.)
Division / Department Center for Medical Devices
Position Professor
URL

http://friend.ucsd.edu/james-friend/

Members

Takahiro Muraoka (Institute of Engineering / Professor)
Hiroshi Tsugawa (Institute of Global Innovation Research / Professor)
Yuta Kurashina (Institute of Engineering / Associate Professor)
Nanami Takeuchi (Institite of Global Innovation Research / Assistant Professor)
Peng Zugui (Institite of Global Innovation Research / Assistant Professor)

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