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Effects of natural compounds on osteoclast differentiation and bone resorption

【LIFE SCIENCE】 Inada Unit 2

  • Overview

    Beta cryptoxanthin (β-cry) is a typical carotenoid found abundantly in fruit and vegetables. Inada-Grundler research group has reported that β-cry suppressed lipopolysaccharide (LPS)-induced alveolar bone destruction. In osteoblasts, β-cry blocked NFκB (nuclear factor κB) pathway activated by LPS, leading to inhibiting PGE2 production. In molecular docking simulation, β-cry could directly bind to the ATP-binging pocket of IKKβ, a signal component of NFκB pathway. β-cry further inhibited IKK kinase activity, however, this effect of β-cry was canceled by ATP in a dose-dependent manner.

    Inada-Grundler team currently studies further functions and the effects of several natural compounds on LPS-induced bone destruction.

Team Head

International Researcher(s)

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