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Effects of hypergravity and microgravity on bone and muscle mass in mice

【LIFE SCIENCE】 Inada Unit 1

  • Overview

    Space flight is known to induce severe systemic bone loss and muscle atrophy of astronauts due to the circumstances of microgravity.  Mechanical loading by exercise recovers the bone and muscle mass to avoid microgravity-induced bone and muscle loss.

    Inada-Itoh research group studies the effects of hypergravity and microgravity on musculoskeletal tissues. We have reported that hypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice by space experiments at Japanese Experimental Module, called as ‘Kibo’, in the International Space Station (ISS) and ground experiments. Microgravity decreased bone mass, on the other hand, 2G hypergravity increased bone and muscle mass (Fig.1.).

    In the analysis for mRNA expression by qPCR, bone formation genes including BMP2 were up regulated, and muscle regulatory genes were up regulated whereas autophagy-related genes were down regulated in 2G-loaded mice. We currently investigate the molecular mechanisms for altered gravity-induced changes of bone and muscle mass.

Team Head

International Researcher(s)

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