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Development of organelle targeting system for solving biomedical issues: From phase separated proteins to small chemical compounds.

【LIFE SCIENCE】 Shinohara Team

  • Overview

    In this project, we will develop an organella-targeting system of proteins and chemical compounds for solving biological open questions and issues on drug-resistant organisms.

  • Approaches

    Dr. Takanari Inoue had developed chemically-controlled targeting system for various types of protein and organelle, to date. In this project, we will apply this technology to phase separated-protein that forms membrane-less organelle in cell and elucidate the interaction between the canonical organelle and membrane-less organelle. In addition, Dr. Micha Fridman had developed organelle-targeting system for anti-microbial compounds. By combining this technology with a screening system in our team, we will propose a novel strategy for overcoming issues on drug-resistant organisms.

  • Plan

    (1) Examination of physicochemical property of liquid-like protein droplets in cell and in vitro.
    (2) Screening of chemical compounds for the organelle –targeting system and its application to drug-resistant organisms.

Team Head

International Researcher(s)

Takanari Inoue

Affiliation Johns Hopkins University(U.S.A.)
Division / Department Department of Cell Biology
Position Professor
URL

https://pages.jh.edu/inouelab/

Micha Fridman

Affiliation Tel Aviv University (Israel)
Division / Department School of Chemistry
Position Associate Professor
URL

http://www3.tau.ac.il/mfridman/

Naoki Yamanaka

Affiliation University of California, Riverside (U.S.A.)
Division / Department Department of Entomology
Position Assistant Professor
URL

https://www.yamanakalab.com/

Ryan J. White

Affiliation University of Cincinnati (U.S.A.)
Division / Department College of Arts & Sciences
Position Associate Professor
URL

https://www.echemnanobio.com/

Members

Ryuji Kawano  (Institute of Engineering / Professor)
Kaori Sakurai  (Institute of Engineering / Associate Professor)

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