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[ LIFE SCIENCE ] Ogino Team

Development of functional nano-capsules and materials for drug delivery systems and other applications

Team Head

Kenji Ogino

Affiliation Institute of Engineering
Division / Department Division of Applied Chemistry
Position Professor
URL http://kenkyu-web.tuat.ac.jp/Profiles/5/0000467/profile.html

Foreign Researcher(s)

Guanghui Ma

Affiliation Chinese Academy of Sciences (China)
Division / Department Institute of Process Engineering
Position Professor
URL http://sourcedb.ipe.cas.cn/yw/fas/200907/t20090717_2091953.html

Aibing Yu

Affiliation Monash University(Australia)
Division / Department Department of Chemical Engineering
Position Professor
URL https://www.monash.edu/engineering/aibingyu

Sanjay Mathur 

Affiliation University of Cologne (Germany)
Division / Department Institute of Inorganic Chemistry / Department of Chemistry / Faculty of Mathematics and Natural Sciences
Position Professor
URL https://mathur.uni-koeln.de/sanjay_mathur0.html?&L=1

Wolfgang Peukert

Affiliation Friedrich Alexander University (Germany)
Division / Department Department of Chemical and Biological Engineering
Position Professor
URL https://www.chemistry.nat.fau.eu/person/wolfgang-peukert/

Members

Eika W. Qian (Institute of Engineering / Professor), Wuled Lenggoro (Institute of Engineering / Associate Professor), Hideaki Tokuyama (Institute of Engineering / Associate Professor) , Yohei Okada (Institute of Engineering / Assistant Professor), Nguyen Thanh Tung (Institute of Global Innovation / Assistant Professor)

Overview

Prof. Ma, the director of National Key Laboratory of Biochemical Engineering in Chinese Academy of Science, synthesizes nano-capsules using polymeric and inorganic materials for the pharmaceutical applications. She carries out the functional designs for the structures of the capsules and the medicines, and experiments on animals in-vitro and in-vivo. She also possesses a variety of pharmaceutical patents, and the pilot plants for manufacturing of capsules. Collaborations of researchers in TUAT, in the fields of the designs and processing of organic and inorganic capsules, and the developments of peptide-based medicines with Prof. Ma make it possible to perform a variety of experiments based on the various tests and evaluations, which are necessary for novel pharmaceutical designs, including affinity with pathological cells, target specificity, sustained release of drugs. Furthermore, collaborations with Prof. Yu novel leads to novel designs for nano- and microcapsules by analyzing the dynamic behaviors of capsules based n computational science. It is also possible to fabricate the capsules with novel functionality based on organic / inorganic materials by the collaboration with Prof. Mathur.

Approaches

1) Background
Much attention has been paid to drug-delivery-systems (DDS) since the target specificity suppress the serious side effects. For example, specially designed carriers containing anticancer drugs can be delivered only to cancer cells not to sound cells. Among various proposed techniques, microcapsules where the surface is chemicall modified so that microcapsules have specific affinity with cancer cells, have been developed. Prof. Ma is the grobal authority in the field of microcapsule based DDS, and carries out the animal experiments for the evaluation of DDS in her research group. In a variety of activities, Prof. Ma launched the venture company collaborated with the pharmaceutical company. For 7-years until 2001, she worked as the assistant professor in TUAT. Since the present achievements are based on the techniques for the fabrication of microcapsules she developed in TUAT, she enthusiastically hopes to collaborate with TUAT researchers.
2) Targets
Basic technologies will be established in 3-years for the development of hybrid capsules with novel functionality by combining the technologies developed in Chinese Academy of Science with various seeds in TUAT in the fields of polymer chemistry, organic chemistry, inorganic nano science, and process engineering.
3) Expected results and impacts
Hithertro pharmaceutical microcapsules have been based mainly on organic and/or polymeric materials. Microcapsules with complex structures and functionality developed by the collaboration of polymer chemists, organic chemists, and inorganic material scientists have never sufficiently investigated. Since the applications in medical practices are advanced in China, Collaboration makes it possible to accelerate the developments of novel DDS systems as well as those for the applications in other fields such as chemical syntheses, catalysts, environmental science.

Plan

1) Fabrication of high performance microcapsules based on the precise structural design
By the combination of techniques in polymer science, organic chemistry, inorganic material science, and process engineering, novel functional microcapsules with complex structures are designed. Organic / inorganic microcapsules with well-defined structure in a nanometer scale are developed in order to afford novel functionalities such as catalytic activity and quantum effect.
2) Evaluation of affinity with pathological cells microcapsules and sustained release performance
The basic properties and functionalities for DDS such as the interaction with biomolecules, sustained release performance and retentivity in artificial biological fluid are evaluated in vitro experiments.
3) Verification of functionalities of capsules by the comparison with experiments on animals, numerical calculations with modeling, and feed back to designs
Based on the results of above-mentioned basic evaluations, especially promising microcapsules are subject to testing on animals to verify the effects. Effective capsule designs and methods are fed back, and the behaviors in organisms are analyzed with computer simulations in order to disclose the action mechanisms.
4) Applications to other fields
The other applications of developed capsules are explored in the fields of catalytic and environmental sciences rather than DDS applications.

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