Institute of Global Innovation Research
Development of organelle targeting system for solving biomedical issues: From phase separated proteins to small chemical compounds.
|Affiliation||Institute of Global Innovation Research|
|Division / Department||－|
|Affiliation||Johns Hopkins University(U.S.A.)|
|Division / Department||Department of Cell Biology|
|Affiliation||Tel Aviv University (Israel)|
|Division / Department||School of Chemistry|
|Affiliation||University of California, Riverside （U.S.A.）|
|Division / Department||Department of Entomology|
|Affiliation||University of Cincinnati (U.S.A.)|
|Division / Department||College of Arts & Sciences|
Ryuji Kawano (Institute of Engineering / Associate Professor), Kaori Sakurai (Institute of Engineering / Associate Professor)
In this project, we will develop an organella-targeting system of proteins and chemical compounds for solving biological open questions and issues on drug-resistant organisms.
Dr. Takanari Inoue had developed chemically-controlled targeting system for various types of protein and organelle, to date. In this project, we will apply this technology to phase separated-protein that forms membrane-less organelle in cell and elucidate the interaction between the canonical organelle and membrane-less organelle. In addition, Dr. Micha Fridman had developed organelle-targeting system for anti-microbial compounds. By combining this technology with a screening system in our team, we will propose a novel strategy for overcoming issues on drug-resistant organisms.
(1) Examination of physicochemical property of liquid-like protein droplets in cell and in vitro.
(2) Screening of chemical compounds for the organelle –targeting system and its application to drug-resistant organisms.
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