Institute of Global Innovation Research

icon

Menu

Institute of Global Innovation Research

Japanese

Life Science

Yearly archive

Yearly archive

[LIFE SCIENCE] Shinohara Team

Development of organelle targeting system for solving biomedical issues: From phase separated proteins to small chemical compounds.

Team Head

Kyosuke Shinohara

Affiliation Institute of Global Innovation Research
Division / Department
Position 特任准教授
URL http://www.tenure-track-tuat.org/scholar/technology/post_54.html

Foreign Researcher(s)

Takanari Inoue

Affiliation Johns Hopkins University(U.S.A.)
Division / Department Department of Cell Biology
Position Professor
URL https://cellbio.jhmi.edu/people/faculty/takanari-inoue-phd

Micha Fridman

Affiliation Tel Aviv University (Israel)
Division / Department School of Chemistry
Position Associate Professor
URL http://www3.tau.ac.il/mfridman/

Naoki Yamanaka

Affiliation University of California, Riverside (U.S.A.)
Division / Department Department of Entomology
Position Assistant Professor
URL https://www.yamanakalab.com/

Ryan J. White   

Affiliation University of Cincinnati (U.S.A.)
Division / Department College of Arts & Sciences
Position Associate Professor
URL https://www.echemnanobio.com/

Members

Ryuji Kawano (Institute of Engineering / Associate Professor), Kaori Sakurai (Institute of Engineering / Associate Professor)

Overview

In this project, we will develop an organella-targeting system of proteins and chemical compounds for solving biological open questions and issues on drug-resistant organisms.

Approaches

Dr. Takanari Inoue had developed chemically-controlled targeting system for various types of protein and organelle, to date. In this project, we will apply this technology to phase separated-protein that forms membrane-less organelle in cell and elucidate the interaction between the canonical organelle and membrane-less organelle. In addition, Dr. Micha Fridman had developed organelle-targeting system for anti-microbial compounds. By combining this technology with a screening system in our team, we will propose a novel strategy for overcoming issues on drug-resistant organisms.

Plan

(1) Examination of physicochemical property of liquid-like protein droplets in cell and in vitro.
(2) Screening of chemical compounds for the organelle –targeting system and its application to drug-resistant organisms.

COPYRIGHT 2019 ©TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY., ALL RIGHTS RESERVED.

Page Topへ

Close the menu